Yihui Shi, M.D. Ph.D

Professor of Biochemistry, Immunology and Physiology

Office: (916) 686-8362

Yihui Shi, M.D. Ph.D


  • MD Wenzhou Medical University, China
  • MS Shanghai Jiaotong University, Medical School, China
  • PhD Wayne State University, Detroit, Michigan


Dr. Yihui Shi is a Professor in the Basic Science Department. Her research focuses on cancer biology. Prior to coming to CNU, she was Director and Senior Research Scientist at Stanford Research Institute (SRI). Dr. Shi received her M.D. in 1994 and practiced medicine for a few years in China. She obtained her Ph.D. in Molecular Biology and Genetics from Wayne State University and subsequently completed a post-doctoral fellowship at UCSF Comprehensive Cancer Center. She has served as PI on multiple collaborative projects with pharmaceutical and biotechnology companies, has served as a leader and key personnel of multiple NIH awards. Her two major projects are currently funded by NIH/NCI grants, one entitled ‘Identification of Synthetic Lethal Partners of Cancer Germline Mutations using Pan-Cancer Human Primary Tumor Data’ as PI and the other entitled ‘HERV-K Blockade to Prevent RAS Activation in Breast Cancer” as subcontract PI. She is also a frontier of employing small molecule splicing modulators to treat cancer and is continuing to explore the application in cancer drug discovery targeting spliceosome.