Overview

Scholarly Activities

(Representative from the last two years)

 

GRANTS  

 

Arias, H.R. (Co-PI). The Åhlen Foundation, Sweden. Project: Experimental strategies for improvement of pharmacological treatment in schizophrenia by selective α7 nicotinic receptor ligands: focus on cognition. International Scientific collaboration with Dr. Marie-Louis Wadenberg, Faculty of Health & Life Sciences, Linnaeus University, Kalmar, Sweden. February, 2015-December 31st, 2016. Total: 100,000 SEK.

 

Arias, H.R. (Co-PI). SONATA funding, National Science Centre, Poland. Project: Analysis of the structural and functional mechanisms of action of nicotinic receptor modulators. International Scientific collaboration with Dr. K. Targowska-Duda, Laboratory of Medicinal Chemistry and Neuroengineering, Department of Chemistry, Medical University of Lublin, Lublin, Poland. March, 2014-February, 2017. Total: 461.950 PLN.

 

 

PUBLICATIONS

Goldstein, M.H., Martel, J.R., Sall, K., Goldberg, D.F., Abrams, M., Rubin, J., Sheppard, J., Tauber, J., Korenfeld, M., Agahigian, J., Durham, T.A., Furfine. E. (2016) Multicenter Study of a Novel Topical Interleukin-1 Receptor Inhibitor, Isunakinra, in Subjects With Moderate to Severe Dry Eye Disease. Eye Contact Lens., in press.

Potasiewicz, A., Hołuj, M., Kos, T.,  Popik, P., Arias, H.R., and Nikiforuk, A. (2016) 3-Furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic receptor, reverses schizophrenia-like cognitive deficits in rats. Neuropharmacology 113 (Part A), 188-197.

Arias, H.R., Feuerbach, D., and Ortells, M. (2016) Bupropion and its photoreactive analog (±)-SADU-3-72 interact with luminal and non-luminal sites at human α4β2 nicotinic acetylcholine receptors. Neurochem. Int. 100, 67-77.

Anders, U.M., Taylor, E.J., Martel, J.R., and Martel, J.B. (2016) Pseudo-Orbital Apex Syndrome in the Acute Trauma Setting Due to Ipsilateral Dissection of Internal Carotid Artery. Ophthal. Plast. Reconstr. Surg. 32, e96-7.

Zhang, Y., Dennis Somtakoune, S., Cheung, C., Listiawan, M., and Feng, X. (2016) Therapeutic Application of Pharmacogenomics in Oncology. AAPS J. 18, 819-829.

Fuenzalida, M., Pérez, M.A., and Arias, H.R. (2016) Role of nicotinic and muscarinic receptors on synaptic plasticity and neurological diseases. Curr. Pharm. Des. 22, 2004-2014 (Thematic issue: Effective and promising treatments for neurological disorders and cancer; Uteshev, V., Ed.).

Arias, H.R., Ravazzini, F., Targowska-Duda, K.M., Kaczor, A.A., Feuerbach, D., Boffi, J.C., Draczkowski, P., Montag, D., Brandon, M.B., Elghoyen, A.B., Jozwiak, K., and Puja, G. (2016). Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.  Int. J. Biochem. Cell Biol. 76, 19-30.

Arias, H.R. (2016) Introduction to the special issue “functional and therapeutic aspects of the nicotinic acetylcholine receptor family”. Neurotransmitter 3, e1306 (2 pages) (Arias, H.R., Ed.).

Atzori, M., García-Oscos, F., and Arias, H.R. (2016) α7 nicotinic acetylcholine receptor-mediated anti-inflammatory actions modulate brain functions. Neurotransmitter 3, e1303 (15 pages) (Special Issue: Functional and therapeutic aspects of the nicotinic acetylcholine receptor family; Arias, H.R., Ed.).

García-Colunga, J., Targowska-Duda, K.M., and Arias, H.R. (2016) Functional and structural interactions between selective serotonin reuptake inhibitors and nicotinic acetylcholine receptors. Neurotransmitter 3, e1293 (11 pages) (Special Issue: Functional and therapeutic aspects of the nicotinic acetylcholine receptor family; Arias, H.R., Ed.).

Andersen, N.D., Nielsen, B.E., Corradi, J., Tolosa, M.F., Feuerbach, D., Arias, H.R., and Bouzat, C. (2016) Exploring the positive allosteric modulation of human α7 nicotinic receptors from a single-channel perspective. Neuropharmacology 107, 189-200.

Dennis Somtakoune, S., Zhang, Y., Todd, M.P., Cohen, H., and Feng, X. (2016) Cancer Vaccines and Immunotherapy for Tumor Prevention and Treatment. US Pharm. 40, 13-18 (Specialty Pharmacy and Oncology Supplement).

Targowska-Duda, K.M., Wnorowski , A., Budzynska, B., Jozwiak, K., Biała, G., and Arias, H.R. (2016) The positive allosteric modulator of α7 nicotinic acetylcholine receptors, 3-furan-2-yl-N-p-tolyl-acrylamide, enhances memory processes and stimulates ERK1/2 phosphorylation in mice. Behav. Brain Res. 302, 142-151.

Jey, A., Hull, P., Kravchuk, V., Carrillo, B., and Martel, J.B. (2016) Emergent diagnosis and management of TASER penetrating ocular injury. Am. J. Emerg. Med. 34, 1740.e3-5.

Sarsekeyeva, M., Poznanski, A., Schumann, H., Brady, D., Akins, R., and Ofstad, W. (2015) A Model for Including the Patient and Family as Team Members: The Geriatric Mentor Interprofessional Education Practice Experience. J. Interprof. Edu. Pract. 1, 69-70.

Arias, H.R., Feuerbach, D., Targowska-Duda, K.M., Kaczor, A.A., Poso, A., and Jozwiak, K. (2015) Pharmacological and molecular studies on the interaction of varenicline with different nicotinic acetylcholine receptors. Potential mechanism underlying partial agonism at human α4β2 and α3β4 subtypes. Biochem. Byophys. Acta – Biomembranes 1848, 731-741.

Atamna, H., Brahmbhatt, M., Atamna, W., Shanower, G.A., and Dhahbi, J.M. (2015) ApoHRP-based assay to measure intracellular regulatory heme (2015) Metallomics 7:309-321.

Cusick, J.K., Hager, E., and Gill, R.E. Identification of a mutant locus that bypasses the BsgA protease requirement for social development in Myxococcus xanthus (2015) FEMS Microbiol Lett. 362, 1-8.

Jogerst, K., Callender, B., Adams, V., Evert, J., Fields, E., Olsen, J., Rowthorn, V., Rudy, S., Shen, J., Simon, L., Torres, H., Velji, A., and Wilson, L.L. (2015). Identifying interprofessional global health competencies for the 21st century health professionals: Authors the Global Health Competency Subcommittee of the Consortium of Universities for Global Health. Ann. Glob. Health 81, 239-247.

Velji, A. (2015) Education for global oral health: progress in improving awareness and defining competencies. J. Dent. Educ. 79, 351-352.

Arias, H.R., Targowska-Duda, K.M., and Jozwiak, K. (2015) N,6-dimethyltricyclo[5.2.1.02,6]decan-2-amine enantiomers interact with the human α3b4 nicotinic receptor at luminal and non-luminal binding sites. J. Biochem. Mol. Biol. Res., 1, 19-24.

Arias, H.R., Feuerbach, D., and Ortells, M.O. (2015) Functional and structural interaction of (-)-lobeline with human α4β2 and α4β4 nicotinic acetylcholine receptor subtypes. Int. J. Biochem. Cell Biol. 64, 15-24.

Arias, H.R., Feuerbach, D., Targowska-Duda, K.M., and Jozwiak, K. (2015) Coronaridine congeners inhibit human α3β4 nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites. Int. J. Biochem. Cell Biol. 65, 81-90.

Arias, H.R., Targowska-Duda, K.M., Feuerbach, D., and Jozwiak, K. (2015) The antidepressant-like activity of nicotine, but not of 3-furan-2-yl-N-p-tolyl-acrylamide, is regulated by the nicotinic receptor β4 subunit. Neurochem. Int. 87, 110-116.

Möller-Acuña, P., Contreras-Riquelme, J.S., Rojas-Fuentes, C., Nuñez-Vivanco, G., Alzate-Morales, J., Iturriaga-Vásquez, P., Arias, H.R., and Reyes-Parada, M. (2015) Similarities between the binding sites of SB-206553 at serotonin type 2 and α7 acetylcholine nicotinic receptors: Rationale for its polypharmacological profile. PLoS ONE 10(8), e0134444.

Bagdas, D., Targowska-Duda, K.M., López, J.J., Pérez, E.G., Arias, H.R., and Damaj, M.I. (2015) Antinociceptive and anti-inflammatory properties of 3-furan-2-yl-N-p-tolyl-acrylamide (PAM-2), a positive allosteric modulator of α7 nicotinic acetylcholine receptors, in mice. Anesth. Analg. 121, 1369-1377.

Potasiewicz, A., Kos, T., Ravazzini, F., Puja, G., Arias, H.R., Popik, P., and Nikiforuk, A. (2015). Pro-cognitive activity in rats of 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor. Br. J. Pharmacol. 172, 5123-5135.

Tauber, J., Karpecki, P., Latkany, R., Luchs, J., Martel, J., Sall, K., Raychaudhuri, A., Smith, V., Semba, C.P. (2105) OPUS-2 Investigators. Lifitegrast Ophthalmic Solution 5.0% versus Placebo for Treatment of Dry Eye Disease: Results of the Randomized Phase II OPUS-2 Study. Ophthalmology 122, 2423-2431.

Anders, U.M., Taylor, E.J., Doty, D.C., Martel, J.R., and Martel, J.B. (2015) Neuroretinitis secondary to Bartonella henselae in the emergent setting. Am. J. Emerg. Med. 33, e1-3.

Anders U.M., Taylor, E.J., Martel, J.R., and Martel, J.B. (2015) Acute orbital apex syndrome and rhino-orbito-cerebral mucormycosis. Int. Med. Case Rep. J. 8, 93-96.

Anders U.M., Taylor, E.J., Kravchuk, V., Martel, J.R., and Martel, J.B. (2015) Stevens-Johnson syndrome without skin lesions: a rare and clinically challenging disease in the urgent setting. Emerg. Med. Open J. 1, 22-30.

Martel, J.B.A., Anders, U.M., and Kravchuk, V. (2015) Comparative study of teleophthalmology devices: Smartphone adapted ophthalmoscope, robotic ophthalmoscope, and traditional fundus camera – The recent advancements in telemedicine. New Front. Ophthalmol. 1.

Doroudgar, S., Perry, P.J., Lackey, G.D., Veselova, N.G., Chuang, H.M., and Albertson, T.E. (2015) An 11-year retrospective review of venlafaxine ingestion in children from the California Poison Control System. Hum. Exp. Toxicol. 34, 1-8.

 

 

BOOKS and BOOK  CHAPTERS

 

Listiawan, M., Feng, M., and Feng, X. (2016) Clinical Applications of Pharmacogenomics in Cancer Therapy. In Applying Pharmacogenomics in Therapeutics (Feng, X. and Xie, H-G., Eds.), pp.143-180.

Listiawan, M., and Feng, X. (2016) Therapeutic Application of Pharmacogenomics in Cancer Treatment: Toxicity Prediction and Minimization. (Feng, X. and Xie, H-G, Eds.). Therapeutic Application of Pharmacogenomics in Patient Care. Taylor & Francis, ISBN: 978-1-4665-8267-5. In press.

Fornari, A., and Poznanski, A. (2015) International Association of Medical Science Educators Manual: How-To-Guide for Active Learning (Fornari, A., and Poznanski, A., Eds.). Springer.

Alemagno, S.A., Carlson, G.P., Clements, J.D., Gordon, S.M., Groopman, J., Laviey, D., Lockey, J.E., Poland, G.A., and Silva, J. (2015) Deployment Pulmonary Health, pp 1-150. Department of Defense, Defense Health Board, Washington DC.

 

 

EDITORIALS

 

Martel, J.B. (2015) The Web of Medicine. Ann. Int. Med. Den. Res. 1, 108-109.

Martel, J.B.A. (2015) Inaugural Message from the Founding Editor-in-Chief. New Front. Ophthalmol. 1

 

 

AWARDS 

 

Hall, M., Kolb, J., Todd Jr., B., Pugh, D., Vance, B., Klienstuber, B., Drecketts, R., Jackson, D., Arias, H.R., and Sudweeks, S.N., 12th Annual Mary Lou Fulton Mentored Student Research Conference, Brigham Young University, Provost, UT, April 7th, 2016. 1st prize for the Neuroscience poster entitled “PAMs: A growing field in pharmacological drug development”.

Pakaj, K., Targowska-Duda, K.M., Budzynska, B., Biała, G., Bogszewska-Czubara, A., Jozwiak, K., and Arias, H.R., 7th Polish Meeting on Medicinal Chemistry, Lublin, Poland, September 17-19, 2015. 1st prize for the poster entitled ” The positive allosteric modulator of the α7 nicotinic receptor, 3-furan-2-yl-N-p-tolyl-acrylamide, has anxiolytic activity without toxicity”.

 

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