Research Centers

Miguel Reyes-Parada, PhD


Academic Title
Professor of Pharmacology
School of Medicine, Faculty of Medical Sciences
University of Santiago de Chile, Chile.

Contact Information
Office Phone: 56 2 2718 3526
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.




Research Projects:
 

Monoamine Oxidase Inhibitors; Structure-activity relationships and structure-based design of drugs acting on monoaminergic synapses; Role of the serotonergic neurotransmission system on different physiological and pathological states.

Current Grants
2013-2016 “Fishing for complements: Design of compounds that simultaneously interact with monoaminergic proteins and nicotinic receptors, based on similarities between their ligand binding sites”. Director. Supported by: FONDECYT, Grant 1130185

2013-2016 “A synthetic approach towards novel series of 3-(3-(1-piperazinyl)propyl-1h-indole derivatives as monoaminergic multi-target agents. Docking studies and pharmacological evaluation at SERT, D2 and MAO-A receptors. Co-investigator. Supported by: FONDECYT, Grant 1130347

Publications (most representatives from the last 3 years):
H. Pessoa-Mahana, C. Ugarte N., R. Araya-Maturana, C. Saitz B., G. Zapata-Torres, C.D. Pessoa-Mahana, P. Iturriaga-Vásquez, J. Mella-Raipán, M. Reyes-Parada, C. Celis-Barros. Synthesis, 5-HT1A receptor affinity and docking studies of 3-[3-(4-aryl-1-piperazinyl)-propyl]-1H-indole derivatives. Chem. Pharm. Bull., 60, 632-638, 2012.

C. Rozas, S. Loyola, G. Ugarte, M.L. Zeise, M. Reyes-Parada, F. Pancetti, P. Rojas, B. Morales. MDMA acutely applied enhances long-term potentiation in the rat hippocampus involving D1 and 5-HT2 receptors through a polysynaptic mechanism. Eur. Neuropsychopharmacol., 22, 584-595, 2012.

A. Fierro, A. Montecinos, C. Gómez-Molina, G. Núñez, M. Aldeco, D. E. Edmondson, M. Vilches-Herrera, S. Lühr, P. Iturriaga-Vásquez , M. Reyes-Parada. Book chapter: “Similarities between the binding sites of monoamine oxidase (MAO) from different species. Is zebrafish a useful model for the discovery of novel MAO inhibitors?” In: “An Integrated View of the Molecular Recognition and Toxinology - From Analytical Procedures to Biomedical Applications”; G. R. Baptista, Editor; ISBN 978-953-51-1151-1, InTech - Open Access Publisher, Rijeka, Croatia, 2013; pp. 504-431.

R. Sotomayor-Zárate, G. Quiroz, K.A. Araya, J. Abarca, M.R. Ibáñez, A. Montecinos, C. Guajardo, G. Núñez, A. Fierro, P.R. Moya, P. Iturriaga-Vásquez, C. Gómez-Molina, K. Gysling, M. Reyes-Parada. 4-Methylthioamphetamine increases dopamine in the rat striatum and has rewarding effects in vivo. Basic Clin. Pharmacol. Toxicol., 111, 371-379, 2012.

H. Pessoa-Mahana, C. González-Lira, A. Fierro, G. Zapata-Torres, C. D. Pessoa-Mahana, J. Ortiz, P. Iturriaga-Vásquez, M. Reyes-Parada, P. Silva-Matus, C. Saitz-Barría, R. Araya-Maturana. Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptor. Bioorg. Med. Chem., 21, 7604-7611.2013.

R. Sotomayor-Zárate, P. Jara, P. Araos, R. Vinet, G. Quiroz, G. M. Renard, P. Espinosa, C. Hurtado-Guzmán, P.R. Moya, P. Iturriaga-Vásquez, K. Gysling, M. Reyes-Parada. Improving amphetamine therapeutic selectivity: N,N-dimethyl-MTA has dopaminergic effects and does not produce aortic contraction. Basic Clin. Pharmacol. Toxicol. 2014 In Press.

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