Research Centers

Katarzyna Targowska-Duda, PhD

Academic Title
Assistant Researcher
Department of Biopharmacy
Medical University of Lublin, Poland

Contact Information
Office Phone: (+4881) 448 72 24
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Research Projects:

Molecular modeling of interaction of various ligands with allosteric binding sites at nicotinic acetylcholine receptors; Structure-activity relationships of allosteric modulators of nicotinic receptors; Animal behavior studies of nicotinic receptors modulators;

Current Grants:
2013 – 2016 “Analysis of the structural and functional mechanisms of action of the nicotinic receptors modulators” Principal Investigator. Project NCN SONATA 5 is supported by National Science Center in Poland (UMO-2013/09/D/NZ7/04549).

2010 – 2014 “Multidisciplinary development of drugs acting on certain neuronal receptors" Co-Investigator. Project TEAM (2009-4/5) is supported by Foundation for Polish Science.

Publications (most representatives from the last 3 years):
Targowska-Duda, K.M., Feuerbach D., Biala, G., Jozwiak, K. Arias, H.R. (2014) Antidepressant activity in mice elicited by 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor. Neurosci Lett569, 126-30.

Arias, H.R., Biala, G., Kruk-Slomka M., Targowska-Duda K.M. (2014) Interaction of nicotinic receptors with bupropion: Structural, functional, and pre-clinical perspectives. Receptors & Clinical Investigation 1, 38-53. 

Bondarenko, V., Targowska-Duda, K.M., Jozwiak, K., Tang, P., Arias, H.R. (2014) Molecular Interactions between Mecamylamine Enantiomers and the Transmembrane Domain of the Human α4β2 Nicotinic Receptor. Biochemistry 53, 908-18.

Targowska-Duda, K.M., Jozwiak, K., Arias, H.R. (2013) Role of the nicotinic receptor β4 subunit in the antidepressant activity of novel N,6-dimethyltricyclo[,6]decan-2-amine enantiomers. Neurosci Lett. 553, 186-190.

Targowska-Duda, K.M., Arias, H.R., Jozwiak, K. (2013) Application of In Silico Methods to Support Experimental Data: Interactions of Antidepressants with Nicotinic Acetylcholine Receptors. Open Conf. Proc. J. 4, 11-22.

Arias, H.R., Targowska-Duda, K.M., Jozwiak, K., (2013) N,6-dimethyltricyclo[,6] decan-2-amine enantiomers interact with the human α4β2 nicotinic acetylcholine receptor at luminal and non-luminal domains. OA Biochemistry 1, 3.

Arias, H.R., Targowska-Duda, K.M., Feuerbach, D., Jozwiak, K. (2013) Mecamylamine inhibits muscle nicotinic acetylcholine receptors by competitive and noncompetitive mechanisms. OA Biochemistry 1, 7.

Arias, H.R., Feuerbach, D., Targowska-Duda, K.M., Aggarwal, S., Lapinsky, D.J., Jozwiak, K. (2012) Structural and functional interaction of (±)-2-(N-tert-butylamino)-3’-iodo-4’-azidopropiophenone, a photoreactive bupropion derivative, with nicotinic acetylcholine receptors. Neurochem. Int. 61, 1433-41.

Arias, H.R., Feuerbach, D., Targowska-Duda, K.M., Jozwiak, K. (2011) Structure-activity relationship of ibogaine analogs interacting with nicotinic acetylcholine receptors in different conformational states. Int. J. Biochem. Cell Biol. 43, 1330-1339.

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