Research Centers

Abel Santamaría-Del Angel, PhD


Academic Title
Senior Researcher
Laboratory of Excitatory Amino Acids, Head
Instituto Nacional de Neurología y Neurocirugía, S.S.A., Mexico

Contact Information
Office Phone: (+5255)5606-3822 (x2013)
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.




Research Projects:

The role of antioxidants in animal models of neurodegenerative disorders; the role of tryptophan metabolites in redox activity in the brain; the role of the cannabinoid system in health and cancer conditions in the CNS; development of animal models of schizophrenia and restrain stress.

Current Grants:
2013-2015 “Fortalecimiento de la infraestructura del Laboratorio de Aminoácidos Excitadores del Instituto Nacional de Neurología y Neurocirugía para la implementación de cultivos organotípicos para el desarrollo de estudios farmacológicos y toxicológicos en el SNC”. Director. Supported by: CONACyT (Consejo Nacional de Ciencia y Tecnología, Mexico), Grant J28612-M.

Publications (most representatives from the last 3 years):
• MALDONADO P.D., PEREZ-DE LA CRUZ V., TORRES-RAMOS M., SILVA-ISLAS C., LECONA-VARGAS R., LUGO-HUITRON R., BLANCO-AYALA T., UGALDE-MUÑIZ P., VAZQUEZ-CERVANTES G.I., FORTOUL T.I., ALI S.F., SANTAMARIA A.: Selenium-induced antioxidant protection recruits modulation of thioredoxin reductase during excitotoxic/pro-oxidant events in the rat striatum. Neurochem. Int. 61: 195-206 (2012).

• COLIN-GONZALEZ A.L., MALDONADO P.D., SANTAMARIA A.: 3-Hydroxykynurenine: an intriguing molecule exerting dual actions in the Central Nervous System. Neurotoxicology 34: 189-204 (2013).

• COLIN-GONZALEZ A.L., OROZCO-IBARRA M., CHANEZ-CARDENAS M.E., RANGEL-LOPEZ E., SANTAMARIA A., PEDRAZA-CHAVERRI J., BARRERA-OVIEDO D., MALDONADO P.D.: Heme oxygenase-1 (HO-1) upregulation delays morphological and oxidative damage induced in an excitotoxic/pro-oxidant model in the rat striatum. Neuroscience 231: 91-101 (2013).

• COLIN-GONZALEZ A.L., SANTAMARIA A.: Probenecid: An Emerging Tool for Neuroprotection. CNS Neurol. Disorders Drug Targets 12: 1050-1065 (2013).

• RADHAKRISHNAN R., SANTAMARIA A., ESCOBAR L., ARIAS H.R.: The β4 nicotinic receptor subunit modulates the chronic antidepressant effect mediated by bupropion. Neurosci. Lett. 555: 68-72 (2013).

• GARCIA E., SANTANA-MARTINEZ R., SILVA-ISLAS C., COLIN-GONZALEZ A.L., GALVAN-ARZATE S., HERAS Y., MALDONADO P.D., SOTELO J., SANTAMARIA A.: S-allyl cysteine protects against MPTP-induced striatal and nigral oxidative neurotoxicity in mice: participation of Nrf2. Free Radical Res. 48: 159-167 (2014).

• COLIN-GONZALEZ A.L., LUNA-LOPEZ A., KÖNIGSBERG M., ALI S.F., PEDRAZA-CHAVERRI J., SANTAMARIA A.: Early modulation of the transcription factor Nrf2 in rodent striatal slices by quinolinic acid, a toxic metabolite of the kynurenine pathway. Neuroscience 260: 130-139 (2014).

• ALARCON-AGUILAR A., LUNA-LOPEZ A., VENTURA-GALLEGOS J.L., LAZZARINI R., GALVAN-ARZATE S., GONZALEZ-PUERTOS D.Y., MORAN J., SANTAMARIA A., KÖNIGSBERG M.: Primary cultured astrocytes from old rats are capable to activate the Nrf2 response against MPP+ toxicity after tBHQ pre-treatment. Neurobiol. Aging In press (2014).

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